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  • Title: The influence of radon measurement errors on the uncertainties of epidemiological case-control studies.
    Author: Zhukovsky M, Onishchenko A, Varaksin A, Vasilyev A.
    Journal: Radiat Prot Dosimetry; 2011 May; 145(2-3):243-7. PubMed ID: 21498865.
    Abstract:
    To analyse the influence of the parameters of case and control groups and uncertainties of radon concentration assessments on the dose-effect dependence, a special computer program was designed. The influence of measurement errors on the uncertainties of radon case-control analysis is demonstrated on examples of hypothetical case and control groups with sizes from 250-500 to 7000-14,000 members. The modelling was conducted using a Monte Carlo technique for different values of measurement uncertainties. The random errors of radon assessment affect both the numerical value of the slope coefficient β of the linear dependence of relative risk of lung cancer incidence on indoor radon concentration and the accuracy of this value. The extrapolation of the dependence of the slope coefficient β on the total (initial plus additional) random error of radon concentration assessment is suggested for the assessment of an unbiased value of the slope coefficient β.
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