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  • Title: Structure-guided redesign of D-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation.
    Author: Gutierrez M, Parella T, Joglar J, Bujons J, Clapés P.
    Journal: Chem Commun (Camb); 2011 May 28; 47(20):5762-4. PubMed ID: 21499643.
    Abstract:
    Structure-guided re-design of the acceptor binding site of D-fructose-6-phosphate aldolase from E. coli leads to the construction of FSA A129S/A165G double mutant with an activity between 5- to >900-fold higher than that of wild-type towards N-Cbz-aminoaldehyde derivatives.
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