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  • Title: Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy.
    Author: Canu E, Agosta F, Baglio F, Galantucci S, Nemni R, Filippi M.
    Journal: Mov Disord; 2011 Aug 01; 26(9):1752-5. PubMed ID: 21500281.
    Abstract:
    BACKGROUND: Diffusion tensor magnetic resonance imaging tractography allows quantification of in vivo white matter tract damage. METHODS: Using tractography, diffusion tensor magnetic resonance imaging metrics were obtained from the superior and middle cerebellar peduncles and major cerebral white matter tracts in 5 patients with progressive supranuclear palsy and 13 controls. RESULTS: Patients showed severe intrinsic damage to the superior cerebellar peduncle, corpus callosum, and cingulum bilaterally. Only decreased axial diffusivity was found in the left middle cerebellar peduncle. CONCLUSIONS: Diffusion tensor magnetic resonance imaging tractography holds promise for providing accurate in vivo cartography of progressive supranuclear palsy tissue damage.
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