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  • Title: [The utility of QuantiFERON TB Gold for diagnosing tuberculous meningitis in children].
    Author: Căliman-Sturdza OA, Mihalache D, Luca CM, Petrovici C, Dorobăţ CM.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2010; 114(4):1048-52. PubMed ID: 21500458.
    Abstract:
    MATERIAL AND METHODS: We performed QuantiFERON-TB Gold in Tube (QFT-G) in blood and CSF at 40 children diagnosed with TB meningitis and at 39 children with non TB meningitis, admitted between October 2006 and December 2009. RESULTS: The CSF analyses were suggestive for TB at 27 patients and only 14 had positive culture. The sensitivity of QFT-G in CSF was 72.72% and 69.44% in blood; specificity 96.96% in CSF and 89.18% in blood; the positive predictive value was 96% in CSF and 86.2% in blood; negative predictive value was 78.04% in CSF and 75% in blood. The sensitivity of TST was 61.76% and specificity 82.05%. The sensitivity of the culture from CSF was only 35%. The sensitivity and specificity of QFT-G was higher than TST and culture and better in CSF than in blood. CONCLUSIONS: The determination of alpha-interferon in serum and CSF is useful diagnostic marker of tuberculosis who could improve the management of TB meningitis.
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