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  • Title: [The expression of visfatin in placenta in women with gestational diabetes mellitus].
    Author: Luo JX, Liu XH, Zhang L, He GL.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2011 Mar; 42(2):204-7. PubMed ID: 21500554.
    Abstract:
    OBJECTIVE: To explore the relationship between the expression of visfatin in placenta and the pathological process of gestational diabetes mellitus (GDM). METHODS: The expression of visfatin mRNA in placenta was measured by RT-PCR in 50 women with GDM (GDM group) and 50 women with normal term pregnancy (control group). The clinical indexes of the pregnant women and their children were assessed by specially trained medical staff. RESULTS: The expression level of visfatin in placenta was as high as house-keeping gene---GAPDH; There was no significant difference in the expression of visfatin between the GDM group and the control group; The partial correlation analysis showed that the expression levels of visfatin mRNA in placenta negatively correlated to glucose screening test (GCT) blood glucose and neonatal body mass index, and positively correlated to body mass index, abdominal circumference and number of pregnancies of the pregnant women. CONCLUSION: Visfatin may be involved in the pathogenesis of gestational diabetes mellitus.
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