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  • Title: Direct stereochemical resolution of aspartame stereoisomers and their degradation products by high-performance liquid chromatography on a chiral crown ether based stationary phase.
    Author: Motellier S, Wainer IW.
    Journal: J Chromatogr; 1990 Sep 21; 516(2):365-73. PubMed ID: 2150410.
    Abstract:
    The direct stereochemical resolution of the four stereoisomers of aspartame (N-DL-alpha-aspartyl-DL-phenylalanine methyl ester) and their degradation products was achieved on a high-performance liquid chromatography chiral stationary phase based upon a chiral crown ether. The chromatographic conditions included a mobile phase composed of aqueous perchloric acid adjusted to a pH of 2.8 and modified with 1.5% of 2-propanol and a temperature gradient. The active L,L-isomer (sold under the brand name NutraSweet) was measured in a diet cola and coffee sweetened with NutraSweet. Degradation products of NutraSweet were also detected but no racemization of stereochemical contamination was observed.
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