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  • Title: Polymeric multilayer capsules delivering biotherapeutics.
    Author: De Koker S, De Cock LJ, Rivera-Gil P, Parak WJ, Auzély Velty R, Vervaet C, Remon JP, Grooten J, De Geest BG.
    Journal: Adv Drug Deliv Rev; 2011 Aug 14; 63(9):748-61. PubMed ID: 21504772.
    Abstract:
    Polymeric multilayer capsules have emerged as a novel drug delivery platform. These capsules are fabricated through layer-by-layer sequential deposition of polymers onto a sacrificial core template followed by the decomposition of this core yielding hollow capsules. The resulting nanometer thin membrane is permselective, allowing diffusion of water and ions but excluding larger molecules. Moreover, the sequential fabrication procedure allows a precise fine-tuning of the capsules' physicochemical and biological properties. These properties have put polymeric multilayer capsules under major attention in the field of drug delivery. In this review we focus on polymeric multilayer capsule mediated delivery of biotechnological macromolecular drugs such as peptides, proteins and nucleic acids.
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