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  • Title: Raman study of the lenses of spontaneously-occurring and streptozotocin-induced diabetic rats.
    Author: Toshima S, Miyazaki H, Mizuno A.
    Journal: Jpn J Ophthalmol; 1990; 34(4):436-41. PubMed ID: 2150537.
    Abstract:
    The WBN/Kob rat is an animal model of spontaneously occurring diabetes only in males at the age of around one year. The diabetic cataract develops about a half year after the onset of diabetes. Using laser Raman spectroscopy we monitored WBN/Kob rat lenses which had chronic hyperglycemic stress and streptozotocin-induced diabetic rat lenses which showed relatively acute cataract formation. WBN/Kob rat lenses revealed a marked increase in the lens water content only in the cortical portion. On the other hand, streptozotocin-induced diabetic rat lenses showed a pronounced increase in the lens water content both in the cortical and the nuclear portion.
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