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  • Title: The blue man: a novel cutaneous manifestation of systemic amyloidosis.
    Author: Campbell M, Rosenthal A, Kundranda M, Pickert A, Dicaudo D, Dogan A, Mikhael J.
    Journal: Amyloid; 2011 Sep; 18(3):156-9. PubMed ID: 21506660.
    Abstract:
    Multiple cutaneous manifestations of amyloidosis have been described, and include periorbital purpura, plaques, nodules, and papules. Blue skin tint is not a previously described feature of cutaneous amyloidosis. We report the clinical case of a patient with known multiple myeloma and amyloidosis of the gastrointestinal tract who presented with progressive "blueness" of the skin. Dermatopathological examination and mass spectrometry of a skin biopsy specimen revealed the presence of subcutaneous amyloid light chain (AL) deposition. We believe this to be the first reported case of blue skin resulting from systemic amyloidosis.
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