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  • Title: [Intraocular levels of pigment epithelium-derived factor in patients with active uveitis].
    Author: Marín-Lambíes C, Salom D, García-Delpech S, Díaz-Llopis M.
    Journal: Arch Soc Esp Oftalmol; 2011 Mar; 86(3):77-80. PubMed ID: 21511101.
    Abstract:
    OBJECTIVE: Pigment epithelium-derived factor (PEDF) is an antiangiogenic/neurotrophic dual functional factor, and recently it was also shown to mediate antioxidative and anti-inflammatory action. The purpose of this study was to evaluate the levels of PEDF in the aqueous humor in eyes with idiopathic acute anterior uveitis (IAAU). METHODS: A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with IAAU. The control group included 20 aqueous humor samples from 20 patients who underwent a cataract surgery and without any other ocular or systemic diseases. Levels of PEDF were determined with the ELISA test. RESULTS: Concentration of PEDF in aqueous humor was remarkably higher in patients with IAAU than in control subjects (Mann-Whitney U test, P<.001). Levels of PEDF were 6,291,637.70±8,564,836.48 pg/ml (mean±SD) in eyes with IAAU and 449,178.10±158,670.19 pg/ml in the eyes of the control group. CONCLUSION: The aqueous humor PEDF levels are increased in eyes with IAAU and may be increased as self-protection against inflammation.
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