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  • Title: Ketamine blocks the plasticity associated with prefrontal cortex self-stimulation.
    Author: Corbett D.
    Journal: Pharmacol Biochem Behav; 1990 Dec; 37(4):685-8. PubMed ID: 2151198.
    Abstract:
    Intracranial self-stimulation (ICSS) at sites within the medial prefrontal cortex (MFC) is acquired slowly but can be hastened by prior exposure to a regimen of noncontingent stimulation delivered to the MFC ICSS electrode. The facilitatory effects of noncontingent MFC stimulation on subsequent ICSS acquisition were blocked by pretreatment with ketamine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. These findings provide further support for the view that the NMDA receptor is importantly involved in mechanisms of neural plasticity.
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