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  • Title: New halogenated phenylcoumarins as tyrosinase inhibitors.
    Author: Matos MJ, Santana L, Uriarte E, Delogu G, Corda M, Fadda MB, Era B, Fais A.
    Journal: Bioorg Med Chem Lett; 2011 Jun 01; 21(11):3342-5. PubMed ID: 21514152.
    Abstract:
    With the aim to find out structural features for the tyrosinase inhibitory activity, in the present communication we report the synthesis and pharmacological evaluation of a new series of phenylcoumarin derivatives with different number of hydroxyl or ether groups and bromo substituent in the scaffold. The synthesized compounds 5-12 were evaluated as mushroom tyrosinase inhibitors showing, two of them, lower IC(50) than the umbelliferone. Compound 12 (IC(50)=215 μM) is the best tyrosinase inhibitor of this series.
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