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  • Title: Selective IgM deficiency in CD30+ cutaneous lymphoproliferative disorder.
    Author: Saini S, Dettore AJ, Bhambhani KJ, Buck S, Poulik J, Savaşan S.
    Journal: J Pediatr Hematol Oncol; 2011 May; 33(4):e156-9. PubMed ID: 21516014.
    Abstract:
    Primary cutaneous anaplastic large cell lymphoma with local lymph node involvement was diagnosed in a 13-year-old boy with an ulcerative facial lesion and a history of skin lesions of lymphomatoid papulosis. The tumor regressed with chemotherapy. He continued to develop recurrent self-limited lesions of lymphomatoid papulosis , with a halo surrounding these lesions during the healing phase. He developed selective immunoglobulin M deficiency with decline in levels even 4 years after the chemotherapy with no recurrent infections noted and adequate IgG response to immunizations. Both peripheral blood IgM+ and memory B cells were low, suggesting a possible cause-effect relationship between selective immunoglobulin M deficiency and chronic CD30+ cutaneous lymphoproliferative disorders.
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