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  • Title: [Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)].
    Author: Gorodetskiĭ VK, Tochilkin AI, Beliaeva NF, Kovel'man IR, Korovkin BF.
    Journal: Biomed Khim; 2011; 57(1):133-7. PubMed ID: 21516785.
    Abstract:
    In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV) with drink water significantly reduced glucose concentration in blood and urine, as well as the level of glycated proteins in the streptozotocin-diabetic rats.
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