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  • Title: Fibulin-5: two for the price of one maintaining pelvic support.
    Author: Northington GM.
    Journal: J Clin Invest; 2011 May; 121(5):1688-91. PubMed ID: 21519147.
    Abstract:
    Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is a complex problem that likely involves multiple mechanisms, and available therapies are limited. In this issue of the JCI, Budatha et al. explore the dual role carried out by fibulin-5 in facilitating the assembly of normal elastic fibers and inhibiting MMP-9 activity, revealing a new mechanism critical to the maintenance of pelvic organ support.
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