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  • Title: Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes.
    Author: André S, Grandjean C, Gautier FM, Bernardi S, Sansone F, Gabius HJ, Ungaro R.
    Journal: Chem Commun (Camb); 2011 Jun 07; 47(21):6126-8. PubMed ID: 21523264.
    Abstract:
    Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter- and intrafamily comparisons) the effect of their combination is examined. In detail, aromatic substituents were introduced at the 2-N or 3'-positions of N-acetyllactosamine and the products conjugated to two types of calix[n]arenes (n = 4, 6) via thiourea-linker chemistry.
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