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  • Title: Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus.
    Author: Qu SJ, Wang GF, Duan WH, Yao SY, Zuo JP, Tan CH, Zhu DY.
    Journal: Bioorg Med Chem; 2011 May 15; 19(10):3120-7. PubMed ID: 21524588.
    Abstract:
    A series of tryptamine derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compounds 2e and 4a showed potent antiviral activity (IC(50)=0.4 and <1 μM, respectively) and low cytotoxicity (CC(50)=40.6 and >25 μM, respectively).
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