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  • Title: In situ monitoring of single molecule binding reactions with time-lapse atomic force microscopy on functionalized DNA origami.
    Author: Wu N, Zhou X, Czajkowsky DM, Ye M, Zeng D, Fu Y, Fan C, Hu J, Li B.
    Journal: Nanoscale; 2011 Jun; 3(6):2481-4. PubMed ID: 21526259.
    Abstract:
    Individual biomolecular binding events were recorded in situ by combining time-lapse atomic force microscopy and DNA origami. Single streptavidin molecules bound to specifically biotinyated DNA origami were simply counted as a function of time to obtain a direct measure of the binding rate.
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