These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Carbamazepine: the bioavailability of 4 oral pharmaceutical products].
    Author: Saavedra I, Passalacqua A, Chávez H, Biagini L, Galdames D.
    Journal: Rev Med Chil; 1990 Oct; 118(10):1123-8. PubMed ID: 2152631.
    Abstract:
    The bioavailability of carbamazepine from 4 commercially available products was evaluated in 12 healthy volunteers. A crossover design was used and each patients received 400 mg of each product. Plasma levels of the drug were determined periodically for 72 h using a gas-liquid chromatographic method. An open model of one compartment for first-order absorption was assumed to derive pharmacokinetic parameters. Dissolution kinetics was also evaluated in each product. Significant differences in bioavailability were shown for one product. Results correlated with the in vitro dissolution findings.
    [Abstract] [Full Text] [Related] [New Search]