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  • Title: 5- and 4'-Hydroxylated flavonoids affect voltage gating of single alpha-hemolysin pore.
    Author: Ostroumova OS, Efimova SS, Schagina LV.
    Journal: Biochim Biophys Acta; 2011 Aug; 1808(8):2051-8. PubMed ID: 21527242.
    Abstract:
    Molecular mechanisms of the influence of flavonoids on the voltage gating of a single alpha-hemolysin channel in planar lipid membranes are studied. It is shown that the addition of flavonoids hydroxylated in position 5 of the A-ring and in position 4' of the B-ring into bilayer bathing solution shifts the voltage dependence of channel switching from high- to low-conductance states to voltages nearer zero. It is concluded that the effect is likely to be attributed to a specific interaction of at least three flavonoid molecules with the voltage sensor of an alpha-hemolysin pore. Possible flavonoid binding sites and identification of amino acid residues included into the voltage sensor domain of the alpha-hemolysin channel are discussed.
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