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  • Title: [The etiopathogenesis of the acute stress ulcer. The role of oxygen free radicals].
    Author: Mancinelli S, de la Fuente G, Manríquez V, Aracena M, Múñoz R, Mancinelli S, Múñoz S.
    Journal: Rev Med Chil; 1990 Sep; 118(9):965-70. PubMed ID: 2152740.
    Abstract:
    We evaluated the role of oxygen free radicals in the induction of acute stress gastric ulcer in rats. After 12 hr of immobility, ulcers of up to 4 mm were observed in the gastric mucosa. Pretreatment with allopurinol, a xanthine oxidase inhibitor, produced a significant reduction in the number and size of lesions (p < 0.0001). No protection was afforded by aluminum hydroxide or ranitidine alone, but enhanced protection was observed when given in association to allopurinol. A secondary role for H ions is suggested by these findings. Our results support the hypothesis of a role of oxygen free radicals in the pathogenesis of stress gastric ulcers. Allopurinol might be used in conditions predisposing to stress in patients.
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