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  • Title: [Cushing's syndrome: the diagnostic and treatment problems in 27 cases].
    Author: González G, Arteaga E, Rodríguez JA, López JM, Michaud P, Codner E.
    Journal: Rev Med Chil; 1990 Sep; 118(9):979-87. PubMed ID: 2152742.
    Abstract:
    Problems of diagnosis and treatment were analyzed in 27 patients with Cushing syndrome (25 confirmed by anatomic findings) followed for a mean of 50 months. The etiology was Cushing disease in 14 (52%), suprarenal tumor in 9 (33%) and ectopic secretion of ACTH in 4 (15%). Determination of plasma cortisol levels at 4 PM or 11 PM was a highly sensitive test for the presence of this syndrome (100%). High resolution computed tomography was considerably more effective than conventional X ray studies of the sella in patients with Cushing disease (42 vs 20%). Treatment has been totally effective in all patients with benign suprarenal lesions. Cure was obtained in 64% of patients with pituitary lesions and 0% of patients with Cushing syndrome associated to malignancy.
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