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  • Title: Should we consider MMF therapy after rituximab for nephrotic syndrome?
    Author: Filler G, Huang SH, Sharma AP.
    Journal: Pediatr Nephrol; 2011 Oct; 26(10):1759-62. PubMed ID: 21533869.
    Abstract:
    The management of steroid-dependent nephrotic syndrome, especially in patients who have failed to respond to cytotoxic drugs, such as cyclophosphamide, remains challenging. Rituximab represents a new (off-label) therapeutic option. In a significant portion of patients, it has a short serum half-life following the recovery of CD20-positive cells. The addition of mycophenolate mofetil (MMF) as a maintenance therapy is also an attractive option, but one which requires testing in a prospective randomized clinical trial with therapeutic drug monitoring and mechanistic ancillary studies.
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