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  • Title: Interference of parathion with mitochondrial bioenergetics.
    Author: Moreno AJ, Madeira VM.
    Journal: Biochim Biophys Acta; 1990 Feb 02; 1015(2):361-7. PubMed ID: 2153406.
    Abstract:
    The organophosphorus insecticide parathion depresses the phosphorylation efficiency of mitochondria as inferred from the decrease of RCR and ADP/O ratios. The transmembrane potential (delta psi) developed by energized mitochondria, and depolarization upon ADP addition are also decreased. Furthermore, repolarization is delayed and resumes at a slower rate. The inhibitory action of parathion on phosphorylation efficiency could be related with the following findings: (1) a direct effect on the succinate dehydrogenase-ubiquinone segment of the redox chain; (2) a direct action on the ATP synthetase complex; (3) partial inhibition of the phosphate transporter.
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