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  • Title: Activation of delta-type opioid receptors modulates the responses of cat terminal ileum to field electrical stimulation.
    Author: Venkova K, Pencheva N, Radomirov R.
    Journal: Gen Pharmacol; 1990; 21(1):123-6. PubMed ID: 2153605.
    Abstract:
    1. The effects of (D-Ala2, D-Leu5) enkephalin amide (DADLE) on the responses of the cat terminal ileum to field electrical stimulation (pulse duration of 0.5 msec, train duration of 10 sec, 30 V) were evaluated by the changes in the contractile or the relaxatory responses of longitudinal and circular strips to electrical stimuli with a frequency of 2, 10 or 30 Hz. 2. Stimulation with a frequency of 2, 10 or 30 Hz elicited contractile responses from the longitudinal strips while in the circular strips 2 Hz stimulation induced contractions and 10 or 30 Hz stimulation caused relaxation. Tetrodotoxin (TTX) (0.1 mumol/l) abolished the electrically-induced responses in both longitudinal and circular strips. 3. DADLE (1 nmol/l) significantly inhibited the cholinergic contractile responses of the longitudinal strips to 2, 10 or 30 Hz stimulation and the contractile responses of the circular strips to 2 Hz stimulation. The relaxatory responses of the circular strips to 10 or 30 Hz stimulation were insignificantly increased by DADLE. 4. On the background of guanetidine (10 mumol/l) and atropine (3 mumol/l) DADLE significantly decreased the nonadrenergic, noncholinergic relaxatory responses of the circular strips to 2, 10 or 30 Hz stimulation. 5. DADLE did not change the maximum effects and the EC50 values of acetylcholine and noradrenaline in both longitudinal and circular strips. 6. It is suggested that in the cat terminal ileum activation of delta-type opioid receptors modulates the mechanical activity suppressing the cholinergic responses in the longitudinal and circular layers as well as the adrenergic and nonadrenergic, noncholinergic responses in the circular layer.
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