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  • Title: Cyanide intoxication--III. On the analogous and different effects provoked by non-lethal and lethal challenged doses.
    Author: Buzaleh AM, Vazquez ES, del Carmen Batlle AM.
    Journal: Gen Pharmacol; 1990; 21(1):27-32. PubMed ID: 2153608.
    Abstract:
    1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-L-methionine (SAM) and thiosulphate were investigated. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and delta-aminolevulinic acid dehydratase (ALA-D) activity. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered.
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