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Title: Evaluation of polysaccharide-based chiral stationary phases in quality control of (S)-mirtazapine. Author: Rao RN, Maurya PK, Guruprasad K. Journal: Biomed Chromatogr; 2012 Feb; 26(2):142-6. PubMed ID: 21538417. Abstract: High-performance liquid chromatographic methods were developed for separation of the enantiomers of mirtazapine and its four process-related substances. The direct separations were achieved on chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak AD-H), cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-H) and cellulose tris(4-methylbenzoate) (Chiralcel OJ-H ). The experimental data were utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on retention and separation. The elution sequence was determined under the optimized separation conditions.[Abstract] [Full Text] [Related] [New Search]