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  • Title: Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors.
    Author: Ramurthy S, Aikawa M, Amiri P, Costales A, Hashash A, Jansen JM, Lin S, Ma S, Renhowe PA, Shafer CM, Subramanian S, Sung L, Verhagen J.
    Journal: Bioorg Med Chem Lett; 2011 Jun 01; 21(11):3286-9. PubMed ID: 21543226.
    Abstract:
    Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.
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