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  • Title: Discovery of an orally available PAR-1 antagonist as a novel antiplatelet agent.
    Author: Lee S.
    Journal: Arch Pharm Res; 2011 Apr; 34(4):515-7. PubMed ID: 21544715.
    Abstract:
    Antiplatelet therapy is a key treatment in atherothrombotic disease and platelet is activated via multiple pathways. Current agents do not interfere with all pathways including the protease-activated receptor-1 (PAR-1) pathway stimulated by thrombin. New antiplatelet agents targeting PAR-1 are aimed to reduce thrombosis ideally without increasing bleeding risk. This article provides a review of the new class of agents, PAR-1 antagonists.
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