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  • Title: [New adamantane derivatives and ways of overcoming the resistance of influenza A viruses to rimantadine and amantadine].
    Author: Shibnev VA, Garayev TM, Finogenova MP, Shevchenko ES, Burtseva EI.
    Journal: Vopr Virusol; 2011; 56(2):36-9. PubMed ID: 21545040.
    Abstract:
    The amino acid and peptide derivatives of 1-adamantane carboxylic acid and rimantadine (18 compounds) have been first synthesized and investigated for their activity against influenza A virus (H1N1, H1N1v). In a series of obtained adamantine derivatives, some compounds have been found to be able to inhibit rimantadine-resistant influenza A virus strains. Thus, the antiviral properties of rimantadine can be restored.
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