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  • Title: Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study.
    Author: Ismailogullari S, Ferahbas A, Aksu M, Baydemir R, Utas S.
    Journal: J Eur Acad Dermatol Venereol; 2012 Jun; 26(6):778-81. PubMed ID: 21545544.
    Abstract:
    BACKGROUND:   There are a few case reports in literature that isotretinoin treatment may alter sleep architecture. Also studies in mice suggest a role of retinoids in the contribution of delta oscillations to the sleep electroencephalography. OBJECTIVES:   The aim of this study was to investigate the effect of isotretinoin treatment on sleep architecture using polysomnography (PSG). PATIENTS AND METHODS:   Twelve severe acne vulgaris patients without any psychiatric and sleep disorders were treated with 0.5 mg/kg of isotretinoin. Clinician-administered acne questionnaire, psychiatric examination, Epworth sleepiness scale and PSG recordings were performed after the first month of treatment. RESULTS:   Sleep efficiency was increased from 83.5% (62.8-89.0%, quartiles) to 89.5% (81.5-93.5%, quartiles; P = 0.036) and sleep latency decreased from 18.0 min (11.1-36.3, quartiles) to 15.5 min (9.3-19.0, quartiles; P = 0.023) following 1-month isotretinoin treatment. There were no significant changes in other sleep parameters of PSG and scores of Epworth sleepiness scale. CONCLUSIONS:   This study suggests that isotretinoin treatment slightly improves night-time sleep without any effects on sleep stages and daytime sleepiness.
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