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  • Title: No effect of oral contraceptives on the metabolism of levetiracetam.
    Author: Sabers A, Christensen J.
    Journal: Epilepsy Res; 2011 Aug; 95(3):277-9. PubMed ID: 21549563.
    Abstract:
    The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.
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