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  • Title: Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump.
    Author: Qin X, Poon B, Kwong J, Niles D, Schmidt BZ, Rajagopal L, Gantt S.
    Journal: Int J Antimicrob Agents; 2011 Jul; 38(1):81-3. PubMed ID: 21549571.
    Abstract:
    Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)(LC) gene not previously described in S. aureus. The native plasmids carrying vga(A)(LC) were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.
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