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Title: Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801). Author: Lyle TA, Magill CA, Britcher SF, Denny GH, Thompson WJ, Murphy JS, Knight AR, Kemp JA, Marshall GR, Middlemiss DN. Journal: J Med Chem; 1990 Mar; 33(3):1047-52. PubMed ID: 2155319. Abstract: Several hydrogenated derivatives of the potent NMDA antagonist 1 have been prepared and evaluated as competitive inhibitors of [3H]-1 binding. These compounds were also tested for their ability to act as noncompetitive antagonists of NMDA in vitro. These studies indicate that two aromatic rings are not strictly required for high-affinity binding or NMDA antagonism.[Abstract] [Full Text] [Related] [New Search]