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  • Title: Mixed phosphane η5-CpRuCl(PR3)2 complexes as ambifunctional catalysts for anti-Markovnikov hydration of terminal alkynes.
    Author: Boeck F, Kribber T, Xiao L, Hintermann L.
    Journal: J Am Chem Soc; 2011 Jun 01; 133(21):8138-41. PubMed ID: 21553862.
    Abstract:
    The catalytic activity of [CpRu(L)(2)(MeCN)]PF(6) (L = 2-diphenylphosphinopyridine with bulky groups at C-6) for anti-Markovnikov hydration of terminal alkynes to aldehydes is retained when one heterocyclic ligand L is replaced by L' = PPh(3). Equal amounts of CpRuCl(PPh(3))(2) (1) and phosphane L in acetone solution equilibrate to a mixture of 1, CpRuCl(L)(PPh(3)) (2), and CpRuCl(L)(2) (3), which acts as highly active in situ catalyst for preparative anti-Markovnikov hydration of alkynes in water-rich media (2 mol % [Ru], 60 °C, 3-18 h in 4:1 (v/v) acetone/water). Reactions were completed in <15 min at 160 °C.
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