These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Toluene diisocyanate-induced conformational changes of serum albumin: a study on repeated inhalations in guinea-pigs.
    Author: Kochman S, Lefebvre S, Bernard J, Maujean A, Cazabat A, Lavaud F, Manfait M.
    Journal: Toxicol Lett; 1990 Feb; 50(2-3):165-71. PubMed ID: 2155482.
    Abstract:
    High responder lines of Hartley guinea-pigs were sensitized by repeated inhalations of toluene diisocyanate (TDI). After 3 weeks, we demonstrated a degree of TDI substitution of the serum-albumin-enriched fraction (AEF) and we ascertained the sensitization of the most exposed animals using PCA methodology. Fourier transform infrared spectroscopy (FT-IR), used to investigate conformational changes in AEF, highlighted the structural modifications of the native protein conformation. Such crucial changes may support, at least in part, the relationship between TDI exposure and triggering of hypersensitivity reactions.
    [Abstract] [Full Text] [Related] [New Search]