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  • Title: External ocular inflammatory effects of lipoxygenase enzyme products.
    Author: Napoli SA, Helm C, Insler MS, Ensley HE, Pretus HA, Feigen LP.
    Journal: Ann Ophthalmol; 1990 Jan; 22(1):30-4. PubMed ID: 2155571.
    Abstract:
    We systematically observed the effects of lipoxygenase enzyme products (5-, 8-, 9-, 12-, and 15-HETE and leukotrienes (LT) C4, D4, and B4) on the external ocular inflammatory process in rabbits. Our results, using 1 and 10 micrograms enzymatic preparations topically applied to the conjunctiva, were consistent with the potent chemotactic activity of 12-HETE and LTB4. Modulation of the inflammatory process can be accomplished better, as a result of our findings, by inhibition of both the lipoxygenase and cyclooxygenase pathways.
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