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  • Title: Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea.
    Author: Huang HC, Wu YC, Shih LY, Lo WC, Tsai CH, Shyu WC.
    Journal: J Neurol; 2011 Nov; 258(11):2054-7. PubMed ID: 21559940.
    Abstract:
    We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) and (99m)Tc-labeled tropane dopamine transporter ((99m)Tc-TRODAT-1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and (99m)Tc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.
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