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  • Title: Secondary metabolites from the root wood of Zanthoxylum wutaiense and their antitubercular activity.
    Author: Huang HY, Ishikawa T, Peng CF, Chen S, Chen IS.
    Journal: Chem Biodivers; 2011 May; 8(5):880-6. PubMed ID: 21560236.
    Abstract:
    Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of five new compounds, wutaipyranol A (1), 8-methoxywutaipyranol A (2), demethoxywutaiensal (3), demethoxywutaiensol (4), and dihydrodemethoxywutaiensol (5), together with six known compounds. Their structures were elucidated by 1D- and 2D-NMR, as well as MS analyses. Among the isolates, wutaipyranol A (1), 8-methoxywutaipyranol A (2), and demethoxywutaiensal (3) exhibited antitubercular activities against Mycobacterium tuberculosis H(37) Rv in vitro, with MIC values of 52.4, 55.6, and 45.8 μg/ml, respectively.
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