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  • Title: Insertion of an LrDNA gene fragment and of filler DNA at a mitochondrial exon-intron junction in Podospora.
    Author: Sainsard-Chanet A, Begel O.
    Journal: Nucleic Acids Res; 1990 Feb 25; 18(4):779-83. PubMed ID: 2156230.
    Abstract:
    A rearrangement of the mitochondrial genome of a long lived mutant of Podospora anserina is presented. It consists in the insertion of 191 bp of the LrDNA gene (coding for the large ribosomal RNA) at the junction between exon1 and intron alpha of gene co1 (coding for subunit 1 of cytochrome oxidase). This insertion is accompanied by a 53 bp deletion of the junction and the presence of extra A and T nucleotides at both sides of the inserted sequence. We discuss possible mechanisms of production of this rearrangement. The presence of extra nucleotides at the recombination junctions suggests that it may pass through a stage of free DNA ends originating from a DNA break at the junction between exon1 and intron alpha of gene co1. The possibility that such a DNA break plays a major role in the instability of the mitochondrial genome is envisaged.
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