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  • Title: Induction of allergen-specific tolerance via mucosal routes.
    Author: Mascarell L, Zimmer A, Van Overtvelt L, Tourdot S, Moingeon P.
    Journal: Curr Top Microbiol Immunol; 2011; 352():85-105. PubMed ID: 21562971.
    Abstract:
    Allergen-specific immunotherapy is the only curative treatment of allergies against insect venom, house dust mites, tree/grass pollens, or cat dander. Subcutaneous immunotherapy is successful to reorient the immune system and re-establish long-term tolerance. However, major drawbacks for using this route include: repeated injections, as well as the risk of anaphylaxis. In this context, alternative mucosal routes of administration are being considered together with the combined use of adjuvants/vector systems and recombinant allergens or peptide fragments. Herein, we review the current status in the use of mucosal routes (i.e., sublingual, oral, intranasal) for allergen-specific immunotherapy, as well as the latest understanding with respect to underlying mechanisms of action.
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