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  • Title: Inhibition of rat brain microsomal Na+/K(+)-ATPase and ouabain binding by mercuric chloride.
    Author: Chetty CS, Rajanna B, Rajanna S.
    Journal: Toxicol Lett; 1990 Mar; 51(1):109-16. PubMed ID: 2156358.
    Abstract:
    This study concerned the effects of mercuric chloride on Na+/K(+)-ATPase and [3H]ouabain binding in rat brain microsomes in vitro. The data showed that HgCl2 inhibited Na+/K(+)-ATPase effectively at micromolar concentrations. The degree of inhibition was decreased with increases in enzyme concentration and incubation time. Variations in the ionic strength of Na+ and K+ did not alter the percent inhibition of Na+/K(+)-ATPase activity by HgCl2. Repeated washings partially restored enzyme activity. The binding of [3H]ouabain to microsomal membranes was inhibited by HgCl2 in a concentration-dependent manner. Cumulative inhibition studies with HgCl2 and ouabain indicated that these inhibitors did not act concurrently and independently on Na+/K(+)-ATPase.
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