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  • Title: Spider toxin (JSTX-3) inhibits the convulsions induced by glutamate agonists.
    Author: Himi T, Saito H, Kawai N, Nakajima T.
    Journal: J Neural Transm Gen Sect; 1990; 80(2):95-104. PubMed ID: 2156531.
    Abstract:
    The effect of a spider toxin (JSTX-3)--a specific blocker of glutamate receptors--on the behavior of mice was studied using an intracerebroventricular (i.c.v.) injection technique. At higher doses (more than 12 nmol/brain), JSTX-3 increased motor activities and induced characteristic symptoms. JSTX-3 at a dose of 4.7 nmol/brain which per se did not produce any abnormal behavior, specifically antagonized quisqualate-induced convulsions but not NMDA- or kainate-induced convulsions. These results indicate that JSTX-3 is a selective antagonist of the quisqualate receptors in the mammalian central nervous system.
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