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  • Title: Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern.
    Author: Delavest M, Even C, Benjemaa N, Poirier MF, Jockers R, Krebs MO.
    Journal: Eur Psychiatry; 2012 Jul; 27(5):369-71. PubMed ID: 21565467.
    Abstract:
    This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.
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