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  • Title: Decomposition of volatile anesthetics in soda lime.
    Author: Fujii K.
    Journal: Drug Metabol Drug Interact; 1997; 13(4):261-70. PubMed ID: 21568804.
    Abstract:
    Soda lime mediated decomposition products of volatile anesthetics--halothane, enflurane, isoflurane and sevoflurane--and the degree of degradation, toxicity and concentration in an anesthetic circuit equipped with a model lung are described. These anesthetics undergo decomposition by soda lime as follows: halothane decomposes to yield difluorochlorobromoethylene and trifluorochloroethane; enflurane decomposes to yield l-chloro-l,2-difluorovinyl difluoromethyl ether; isoflurane decomposes to yield 2,2-difluoro-l-chlorovinyl difluoromethyl ether and fluoroform; sevoflurane decomposes to yield fluoromethyl 2,2-difluoro-l-(trifluoromethyl)vinyl ether, fluoromethyl 2-methyl-2,2-difluoro-l-(difluoromethylene)ethyl ether, two isomers of fluoromethyl 2-methoxy-2-fluoro-l-(trifluoromethyl)vinyl ether and fluoromethyl 2,2-difluoro-l-(difluoromethoxy ethyl)vinyl ether. Almost all degraded compounds of these volatile anesthetics are produced by elimination of hydrofluoride from adjacent carbon atoms by soda lime.
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