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  • Title: Hypothalamic corticotrophin releasing factor activity in dogs with pituitary-dependent hyperadrenocorticism.
    Author: Meijer JC, Mulder GH, Rijnberk A, Croughs RJ.
    Journal: J Endocrinol; 1978 Nov; 79(2):209-13. PubMed ID: 215690.
    Abstract:
    Hypothalamic corticotrophin releasing factor (CRF) activity was determined in five dogs with spontaneous hyperadrenocorticism and in three control animals (one untreated, one treated with high doses of ACTH for 2 months and one treated with high doses of cortisone for 2 months). Hypothalamic CRF activity was low or undetectable in four dogs with Cushing's syndrome due to an adrenocortical tumour. The results are compatible with a pituitary origin for pituitary-dependent hyperadrenocorticism in the dog but are not conclusive; direct information about the rates of hypothalamic CRF secretion is required.
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