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  • Title: Separation/preconcentration methods for the determination of aluminum in dialysate solution and scalp hair samples of kidney failure patients.
    Author: Khan S, Kazi TG, Baig JA, Afridi HI, Kolachi NF.
    Journal: Biol Trace Elem Res; 2011 Dec; 144(1-3):205-16. PubMed ID: 21573872.
    Abstract:
    A new method is reported for the separation of aluminum ions (Al(3+)) from interfering cations in pharmaceutical and biological samples through solid-phase extraction (SPE) using 2-methyl-8-hydroxyquinoline (8-hydroxyquinaldine) on activated silica. While separated Al(3+) was preconcentrated by cloud point extraction (CPE) using 3,5,7,2'-4'-pentahydroxyflavone (morin) as complexing reagent, the resulting complex was entrapped in nonionic surfactant (Triton X-114) as prior step to its determination by spectrofluorimetry (SPF). The validity of separation/preconcentration of Al(3+) was checked by certified reference material of human hair and standard addition method. The chemical variables affecting the analytical performance of the separation/preconcentration methods were studied and optimized. The enrichment factor and detection limit of Al(3+) for the preconcentration of 10 ml of dialysate solution and acid-digested samples of scalp hair samples were found to be 25 and 0.34 μg/L, respectively. The relative standard deviation for six replicates of standard containing 20 μg/L of Al(3+) was <10%. In all DS, the concentration of Al was >10 μg/L. The level of Al in scalp hair samples of kidney failure patients was higher than healthy controls.
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