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  • Title: Antenatal maternal anxiety is associated with problem behaviour at age five.
    Author: Loomans EM, van der Stelt O, van Eijsden M, Gemke RJ, Vrijkotte T, den Bergh BR.
    Journal: Early Hum Dev; 2011 Aug; 87(8):565-70. PubMed ID: 21576004.
    Abstract:
    BACKGROUND: Developmental programming by maternal stress during pregnancy is found to influence behavioural development in the offspring. AIM: To prospectively investigate the association between antenatal maternal anxiety and children's behaviour rated by their mothers and teachers. METHODS: In a large, community based birth-cohort (the ABCD-study) antenatal maternal state-anxiety (M = 36.7, SD = 9.8) was measured around the 16th week of gestation. Five years later, 3,446 mothers and 3,520 teachers evaluated 3,758 children's overall problem behaviour, emotional symptoms, conduct problems, hyperactivity/inattention problems, peer relationship problems and pro-social behaviour. RESULTS: Hierarchical multiple regression analysis using a large number of potential covariates revealed that children of mothers who reported higher levels of anxiety during their pregnancy showed more overall problem behaviour, hyperactivity/inattention problems, emotional symptoms, peer relationship problems, conduct problems and showed less pro-social behaviour when mothers rated their child's behaviour. When teachers rated child behaviour, children showed more overall problem behaviour and less pro-social behaviour that was related to antenatal anxiety. The child's sex moderated the association between antenatal anxiety with overall problem behaviour and hyperactivity/inattention problems when reported by the mother. In boys, exposure to antenatal anxiety was associated with a stronger increase in overall problem behaviour compared to girls. Furthermore, antenatal anxiety was significantly related to an increase in hyperactivity/inattention problems in boys, while this was not the case in girls. CONCLUSIONS: Exposure to antenatal maternal anxiety is associated with children's problem behaviour, with different outcome patterns for both sexes. Nevertheless, effect sizes in this study were small.
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