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  • Title: Comparative controlled clinical trial of pivmecillinam and nalidixic acid in patients with acute simple urinary tract infections.
    Author: Kurokawa K, Fujimura N.
    Journal: Jpn J Antibiot; 1978 Dec; 31(12):701-11. PubMed ID: 215795.
    Abstract:
    We performed a controlled double-blind clinical study with PMPC to investigate its therapeutic usefulness in acute simple cystitis in comparison with NA, with the results as follows: 1. In both treatment groups, PMPC proved to be remarkably more active (MIC) than NA against the bacterial isolates tested in vitro. 2. PMPC, administered in dosis (200 mg per day) one-tenth those of NA (2,000 mg per day), produced a greater improvement (therapeutic effects) than NA. 3. Side-effects were apparently less frequent with PMPC, as compared to NA. The results indicate a remarkable usefulness of PMPC in the treatment of acute simple cystitis.
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