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  • Title: Transacting transcriptional activation of human spumaretrovirus LTR in infected cells.
    Author: Rethwilm A, Mori K, Maurer B, ter Meulen V.
    Journal: Virology; 1990 Apr; 175(2):568-71. PubMed ID: 2158186.
    Abstract:
    The long terminal repeat (LTR) of the human spumaretrovirus (HSRV) was examined with respect to its ability to function as transcriptional promotor in virus-infected and uninfected cells. Transient transfections using a plasmid in which the 3' LTR of HSRV was coupled to the bacterial chloramphenicol acetyltransferase (cat) gene revealed that the level of HSRV LTR-directed cat gene expression was markedly increased in HSRV-infected cells compared to uninfected cells. Northern blot analysis of cat mRNA from transfected cultures suggests that transactivation of HSRV-directed gene expression occurs at the transcriptional level.
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